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Discovery of a second protein neuropilin-1 (NRP1) in human cells that enhances COVID-19 infection

Updated: Jun 28, 2020

 

Recently, researchers have recognized a second protein, neuropilin-1 that the virus uses to make entry into human cells. The human protein neuropilin-1 known to bind furin-cleaved substrates aids in the viral infection and found its highest expression in the olfactory epithelium and endothelial cells. Besides, results from the study conclude the potentiality of SARS-CoV-2 to infect brain tissue and suggest its entry into the brain through the olfactory epithelium cells.

Nos on the global death from the disease Covid-19 is already bad and the fact that people with no symptoms can transfer the virus unknowingly, make the whole situation more worrisome. Recently, Vietnam organized a huge coronavirus-testing campaign and found that infected people having no symptoms can pass on the virus. The study published in the journalClinical Infectious Diseasesshows that the infection of SARS-CoV-2 in asymptomatic individuals is common. Since NTS viral loads fall rapidly in asymptomatic individuals, massive nos. of infected individuals can go undetected if not used proper sampling sites.

Researchers around the world are developing over 135 vaccines against the disease, and two of them made it to Phase III trial. The development of vaccines usually takes several years until it can finally make to the clinic. But scientists are hoping to produce one by next year.


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